替硝唑胃内滞留漂浮型缓释片的制备及体外释放研究
替硝唑,,替硝唑；胃内漂浮片；缓释片；释放度,1仪器与试药,2实验方法与结果,3讨论,参考文献:
摘要:目的 根据流体动力学平衡控释系统(HBS)原理研制替硝唑胃内滞留漂浮型缓释片。方法 以释放度为指标，并结合漂浮性能，优选最佳配方。结果 最佳配方的替硝唑胃内滞留漂浮型缓释片体外漂浮时间长达12 h，体外药物释放符合零级过程。结论 本文制备工艺简单，所制得的胃内漂浮缓释片释药速度平稳，漂浮时间长，达到了设计要求。关键词:替硝唑；胃内漂浮片；缓释片；释放度
Preparation and in vitro release of tinidazole floating oral delivery system
ZHOU Yisheng,LU Yi,SONG Hua,ZHAI Dongyan,DUAN Qionghui3
(1. Guangdong College of Pharmacy,Guangzhou 510006,China; 2. Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 3. Henan College of Traditional Chinese Medicine,Zhengzhou 450008,China)
Abstract: Objective Floating oral delivery tablets with controlled release of tinidazole were designed. Method The in vitro release rate of the tablets capable of floating on simulated gastric fluids was evaluated by rotating basket method. The preparation techniques of the tablets were optimized according to the release tests. Results The tablets at optimum formulation could float on artificial gastric fluid for 12 h,and the in vitro release profile of the tablets followed the zero-order kinetics. Conclusion This floating oral delivery system of tinidazole has potential benefits of therapy. ......
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