【摘要】 目的 报告2例食用麻辣火锅后发生的脱髓鞘脑病，并探讨其可能发病机制。方法 记录、分析2例患者的临床表现，实验室辅助检查资料及治疗经过。结果 2例患者均为急性发病，主要表现为中枢神经系统受累症状、体征；在大脑皮质下白质，颅脑核磁共振成像(MRI)T1和T2加权像显示多发点、片状异常信号影，马根维显(Gd-DTPA)静注T1显示增强效应；皮质类固醇激素治疗显效；4年后随诊无复发。结论 食用麻辣火锅后发生的脱髓鞘脑病可能与激活自身免疫反应或某些物质对髓鞘的毒性作用有关。

    【关键词】 麻辣火锅；脱髓鞘脑病

    【Abstract】 Objective To report two patients with demyelinating encephalopathy after having peppery spicy chafing dish,and study the possible mechanism of it.Methods Clinic manifestations,laboratory and assistant examination data,treatment of two cases were described.Other neurologic diseases were excluded.Results Both were acute onset,systems and signs indicated that central nervous system were mainly involved.MRI showed multiple macula areas of abnormal signal intensity in T1 and T2-weighted images in white matter under subcotex,enhancing after gadolinium injected intravenously in the T1weighted sequences.Both patients recovered rapidly after treatment with steroid.There has been no relapse during the follow-up of 4 years.Conclusion Demyelinating encephalopathy duo to peppery spicy chafing dishes may be related with self-immunological response and some matter toxic to the myelin. ......