阿莫西林；_____阿莫西林；高效毛细管电泳法；混悬剂

高效毛细管电泳法测定阿莫西林口服混悬剂中阿莫西林的含量

http://www.100md.com 《广东药学院学报》 2004年第2期

阿莫西林；,,阿莫西林；高效毛细管电泳法；混悬剂,1仪器与试药,2方法与结果,3讨论

     摘要目的：测定阿莫西林口服混悬剂中阿莫西林的含量。方法：高效毛细管电泳法。毛细管60 cm×75μm，运行缓冲液30 mmol/L硼砂(pH 9.2)，高压进样5 s，分离电压12 kV，温度为25 ℃，检测波长254 nm，阿魏酸为内标。结果：阿莫西林在6～30 μg/mL质量浓度范围内线性关系良好(r=0.9996)，平均回收率99.10%(n=5，RSD=1.89%)。结论：本法简单、快捷、灵敏。

    关键词阿莫西林；高效毛细管电泳法；混悬剂

    ADetermination of amoxycillin in amoxycillin oral suspension by HPCE

    GUO Dan, CHEN Nana, WANG Xiangdong, YANG Li，CHEN Zhiliang

    (1. Pharmaceutical Department of Nanfang Hospital, the First Military Medical University, Guangzhou 510515; 2. Institute of Materia Medica, the First Military Medical University, Guangzhou 510515)

    Abstract Objective: to determine the content of amoxycillin in amoxycillin oral suspension. Methods: HPCE was used. The best condition was achieved with a fused silca capillary tube (60 cm×75 μm), 30 mmol/L sodium tetraborate decahydrate buffer (pH 9.2), at a constant voltage of 12 kV and temperature at 25 ℃. The UV detection wavelength was at 254 nm and ferulic acid was determinaed with internal standard method. Results: the calibration curves was linear in the range of 4～20 μg/mL for amoxycillin(r=0.9997). The average recovery of amoxycillin was 99.10% (n=5 ......

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