酚氯伪缓释片_____酚氯伪缓释片；释放度;桨法加沉降篮

酚氯伪缓释片的释放度试验研究

http://www.100md.com 《广东药学院学报》 2004年第3期

酚氯伪缓释片,,酚氯伪缓释片；释放度;桨法加沉降篮,1主要仪器设备和试药,2实验方法及结果,3讨论,参考文献

     摘要目的：研究酚氯伪缓释片释放度的试验条件。方法：采用“桨法加沉降篮”的溶出度测定方法，用0.1 mol/L盐酸溶液和不同pH值的缓冲液作介质。结果与结论：用0.1 mol/L盐酸液作介质，转速100 r/min时，本品与国外的Clariflu*缓释片的释放曲线比较接近。

    关键词酚氯伪缓释片；释放度;桨法加沉降篮

    Dissolution rate of loratadina+pseudoefedrina+paracetamol sustained-release tablets

    XIE Wei si，NIE Qingchun，LIU Qingfei

    (Guangzhou Institute of Pharmaceutical Industry, Guangzhou Guangdong 510240; Guangzhou University of Traditional Chinese Medicine, Guangzhou Guangdong 510405)

    Abstract Objective: to determine the test conditions for dissolution rate of loratadina+pseudoefedrina+paracetamol sustained-release tablets. Methods: Paddle stirring and rotating basket method was used to determine the release rate with different solvants of 0.1 mol/L HCl and various buffers. Results: the release curve of loratadina+pseudoefedrina+paracetamol sustained-release tablets was similar to that of Clariflu of Schering with 0.1 mol/L HCl as solvant with the speed of 100 r/min. ......

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