脑伤宁治疗脑外伤后综合征的药效学研究
脑伤宁,,脑伤宁；脑外伤后综合征；药效学,1材料和仪器,2方法与结果,3讨论
摘 要 目的：研究脑伤宁的主要药效学，为其临床应用提供理论依据。方法：采用热板法及扭体法观察脑伤宁的镇痛作用，观察对小鼠戊巴比妥钠催眠协同作用，以及高粘模型大鼠的血液流变学指标的影响。结果：脑伤宁能明显提高小鼠热痛阀值，减少醋酸所致小鼠扭体反应次数，对戊巴比妥钠催眠有明显协同作用，可使高粘模型大鼠的全血粘度、血浆粘度及红细胞压积明显降低。结论：脑伤宁有助于脑外伤后综合征临床症状的改善。关键词 脑伤宁；脑外伤后综合征；药效学
Pharmacodynamic study of Naoshangning rescription on posttraumatic syndrome
WANG Fang,ZHOU Ke,YU Enxin
(1.Dept. of Pharmacy; 2.Dept. of Neurology,Peoples Hospital of Wuhan Universily,Wuhan,Hubei 430060; 3.Dept. of Pharmacology,Hubei Institute for Drug Control,Wuhan,Hubei 430064)
Abstract Objective: To study the main pharmacodynamics of Naoshangning in order to provide theoretical basis on its clinical application. Methods: The analgesic effect of Naoshangning prescription were examined through hotplate method and writhing method,sleeppromoting test in combination with phenobarbital sodium was conducted,the hemorheology parameters were examined in experimental hyperviscosity model rats. Results:NAOSHANGNING obviously prolonged the incubation period of pain induced by heat stimulation,decreased the fiequency of body torsion induced by acetic acid,potentiated hypnotic effect of phenobarbital sodium at subthreshold dose in mice,significantly improved the hemorheology parameters in experimental hyperviscosity model rats,leading to decrease of whole blood viscosity,plasma viscosity and Hct. Conclusion: Naoshangning prescription is effective in clinical treatment of posttraumatic syndrome. ......
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