Protective effect of insulinª²like growth factors on early pregnancy

    ZHANG Miª²Na, YU Yueª²Cheng, HUANG Kan, SONG Hui, ZHANG Hongª²Ju, WANG Xiaoª²Hong

    PLA 17 Hospital, Kuche 842000, China, Department of Obstetrics & Gynecology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To detect the expressions of insulinª²like growth factorª²¢ñ (IGFª²I) in villus and IGFª²II in decidua and the levels in mother serum, and to explore their relationship with the embryogenesis of early pregnancy. METHODS: Expressions of IGFª²I and IGFª²II were examined by immunohistochemical SP method; the mRNA expressions of IGFª²I and IGFª²II were detected by in situ hybridization (ISH); serum IGFª²I and IGFª²II levels were determined by enzymeª²linked immunosorbent assay (ELISA). RESULTS: The expressions of IGFª²I and IGFª²II both protein and mRNA were lower in the abnormal villus and decidua of pregnancy termination than those of normal villus and decidua of normal pregnancy (P<0.01). Serum levels of IGFª²I and IGFª²II in normal pregnancy women were much higher than those of abnormal pregnancy women(P<0.01). CONCLUSION: IGFª²I and IGFª²II may play important roles in the regulation of fetal growth, the decrease of IGFª²I and IGFª²II levels in villus, decidua and serum may be the key factor contributing to the embryogenesis termination of early pregnancy. So IGFª² I and IGFª²II can serve as 2 parameters in examining the fetal safety. ......