乙肝病毒大蛋白检测在乙型肝炎诊治中的临床意义
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乐爱平, 鞠北华, 王 文, 张文景
乙型肝炎病毒;大蛋白;HBVDNA;乙型肝炎病毒前S1抗原;乙型肝炎病毒前S2抗原;酶联免疫吸附试验;荧光定量聚合酶链反应乐爱平,鞠北华,王文,张文景.乙肝病毒大蛋白检测在乙型肝炎诊治中的临床意义.&
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乐爱平, 鞠北华, 王文, 张文景, 南昌大学第一附属医院检验科 江西省南昌市 330006
乐爱平, 江西医学院医学检验专业毕业, 学士, 讲师, 主要从事临床免疫学的教学、临床与科研工作.
通讯作者: 乐爱平, 330006, 江西省南昌市永外正街17号, 南昌大学第一附属医院检验科. leaiping@126.com
电话: 0791-8692785
收稿日期: 2006-03-14 接受日期: 2006-03-24
Clinical significance of serum hepatitis B virus large surface protein in diagnosis and treatment of patients with hepatitis B
Ai-Ping Le, Bei-Hua Ju, Wen Wang, Wen-Jing Zhang
Ai-Ping Le, Bei-Hua Ju, Wen Wang, Wen-Jing Zhang, Department of Clinical Laboratory, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Correspondence to: Dr. Ai-Ping Le, Department of Clinical Laboratory, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China. leaiping@126.com
Received: 2006-03-14 Accepted: 2006-03-24
Abstract
AIM:To discuss the clinical significance of hepatitis B virus large surface protein (HBV-LP) detection in the diagnosis and treatment of patients with hepatitis B.
METHODS:Enzyme-linked immunosorbent assay was used to measure the levels of serum HBV-LP, HBV preS1, HBV preS2 and HBV markers, and fluorescence quantitative-polymerase chain reaction (FQ-PCR) was used to detect HBV DNA in 162 patients with hepatitis B as well as 47 normal controls.
RESULTS:In serum samples of the patient with HBV infection, the level of HBV-LP had significant correlation with that of HBV DNA, HBeAg, HBVpreS2 and HBVpreS1 antigen (c2 = 9.22, 11.89, 60.35, 99.87; all P < 0.01). The contents of serum HBV-LP was positively correlated with HBV DNA copies (rs = 0.64, P < 0.001). The level of serum HBV-LP was also significantly different between the groups with different HBV DNA copies (P < 0 ......
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