骨肿瘤端粒酶活性检测及其意义
鍏抽敭璇嶏細骨肿瘤,,骨肿瘤;端粒;末端转移酶,0引言,1材料和方法,2结果,3讨论,【参考文献】
Detection of telomerase activity in bone tumors and its significance
HUANG LuYu1,LI Jing1,HUANG SuHua2,TAO HuiRen1,HAN LiHua1,ZHU JinYu1,LIU Jian1
1Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xian 710033, China, 2Department of Cosmetology, PLA 251st Hospital, Zhangjiakou 075000, China
【Abstract】 AIM: To investigate the correlation between the telomerase activity and the pathologic grade of bone tumors. METHODS: The telomerase activity was detected in bone tumors by TRAP and TRAPAg+ staining methods. RESULTS: The telomerase positivity rate was 80.6% for osteosarcoma, 85.7% for chondrosarcoma, 100% for malignant fibrous histocytoma, rhabdomyosarcoma and chordoma, and 11.1% for chondroma, respectively. The telomerase activity in muscle tissues or soft tissues beside the invasive bone tumor tissues in 17 cases was also detected with negative result. CONCLUSION: There is a significant correlation between the telomerase activity and the pathologic grade of bone tumors. The telomerase activity is a good index of diagnosis and prognosis for malignant bone tumors. ......
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