当前位置: 首页 > 期刊 > 《第四军医大学学报》 > 2005年第11期
编号:11006975
骨肿瘤端粒酶活性检测及其意义
鍏抽敭璇嶏細骨肿瘤,,骨肿瘤;端粒;末端转移酶,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Detection of telomerase activity in bone tumors and its significance

    HUANG LuYu1,LI Jing1,HUANG SuHua2,TAO HuiRen1,HAN LiHua1,ZHU JinYu1,LIU Jian1

    1Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xian 710033, China, 2Department of Cosmetology, PLA 251st Hospital, Zhangjiakou 075000, China

    【Abstract】 AIM: To investigate the correlation between the telomerase activity and the pathologic grade of bone tumors. METHODS: The telomerase activity was detected in bone tumors by TRAP and TRAPAg+ staining methods. RESULTS: The telomerase positivity rate was 80.6% for osteosarcoma, 85.7% for chondrosarcoma, 100% for malignant fibrous histocytoma, rhabdomyosarcoma and chordoma, and 11.1% for chondroma, respectively. The telomerase activity in muscle tissues or soft tissues beside the invasive bone tumor tissues in 17 cases was also detected with negative result. CONCLUSION: There is a significant correlation between the telomerase activity and the pathologic grade of bone tumors. The telomerase activity is a good index of diagnosis and prognosis for malignant bone tumors. ......

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