肝脏_____缺血再灌注损伤；一氧化氮；肝脏；大鼠

大鼠肝脏缺血再灌注损伤早期一氧化氮的变化及其作用

http://www.100md.com 《第四军医大学学报》 2005年第11期

肝脏,,缺血再灌注损伤；一氧化氮；肝脏；大鼠,大鼠肝脏缺血再灌注损伤早期一氧化氮的变化及其作用,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Changes and effect of nitric oxide during early hepatic I/R injury in rats

    NAN Jing, DU XiLin, MA QingJiu, LU JianGuo, HE XianLi, BAO GuoQiang

    Department of General Surgery，Tangdu Hospital，Fourth Military Medical University， Xian 710038，China

    【Abstract】 AIM: To investigate the changes of nitric oxide and its effect during hepatic I/R injury. METHODS: One hundred and fifteen male SD rats were divided into four groups: GroupⅠ: sham operation; Group Ⅱ: 70 min ischemia followed by reperfusion with saline given intravenously; GroupⅢ: Larg; GroupⅣ: LNNA plus Larg. Rats were sacrificed at 0, 1, 3, 6 and 12 h after reperfusion. Serum NO, ALT, MDA and plasma TNFα were detected. RESULTS: Serum NO in Group Ⅱ was higher than that in GroupⅠ just after reperfusion but it then decreased significantly. Serum ALT and MDA elevated in GroupⅡ. There were significant differences at 1-6 h after reperfusion (P<0.05). Plasma TNFα increased significantly after 3 h (P<0.05). Larg, the NO donor, significantly reversed these changes (P<0.05). CONCLUSION: Serum NO decreases 1 h after hepatic ischemiareperfusion. It may play an important role in the hepatic I/R injury. ......

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