Comparative study of bronchi artery radioembolization with phosphorusª²32 glass microspheres and interventional chemotherapy alone in patients with intermediate and advanced lung cancer

    CHEN Zhangª²Qin1, WU Changª²Gui1, TI Xinª²Yu1, DAI Yanª²Li1, LI Shuª²Jun1, HE Hongª²De2, SUN Liª²Jun2

    1Department of Respiratory Medicine, 2Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To compare the clinical effects of interventional chemotherapy combined with bronchi artery radioembolization with phosphorusª²32 glass microspheres (32Pª²GMS) and the effects of interventional chemotherapy on patients with advanced lung cancer. METHODS: A total of 48 patients with intermediate and advanced lung cancer were enrolled in the study, including 9 adencarcinoma cases, 24 squamous carcinoma cases, 1 adenosquamous carcinoma and 14 small cell lung carcinoma cases. All the patients received 2 cycles of systemic chemotherapy [cyclophosphamide adrimycin platinum (CAP) remedy for nonª²small cell lung cancer (NSCLC) and VPª²16 platinum (EP) for small cell lung cancer (SCLC)] and were randomized into the experimental group and control group by order of their admission. At the fourth week after the second cycle, the experimental group was given interventional chemotherapy (CAP) combined with bronchi artery radioembolism with 32PGMS, while the control group was only treated by interventional chemotherapy (CAP) alone. RESULTS: In the experimental group, 21% (5/24) achieved complete remission (CR), 62% (15/24) achieved partial remission (PR), 12% (3/24) had no real changes and 1 patient deteriorated (4%). The overall response (CR+PR) rate was 83% (20/24). However, in the control group, 8% (2/24) achieved CR, 42% (10/24) CR, 33% (8/24) had no real changes and 4 patients deteriorated (17%). The overall response (CR+PR) rate was 50% (12/24). The differences of overall response rate between the two groups were statistically significant (83% vs 50%, ¦Ö2=6.00, P=0.01). The incidence of major postoperative complications in both groups was of no significant difference (8% vs 17%, P=0.666). CONCLUSION: The shortª²term effect of chemotherapy combined with bronchi artery radioembolization with 32Pª²GMS is better than that of chemotherapy alone. But the incidence of major side effects in both groups is of no significant difference. ......