肉桂油治疗小鼠CVB3m病毒性心肌炎的实验研究
病毒性心肌炎,,病毒性心肌炎;柯萨奇病毒B3m;肉桂油;肌酸激酶同工酶,0引言,1材料和方法,2结果,3讨论,【参考文献】
Effect of Oleum Cinnamomi on mice viral myocarditis caused by CVB3mDING YuanYuan1, XIE YanHua1, MIAO Shan1, LIAO Bo2, WANG SiWang1
1Institute of Materia Medica, School of Pharmacology, Fourth Military Medical University, Xian 710033, China, 2Department of Orthopaedic, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China
【Abstract】 AIM: To investigate the therapeutic effect of Oleum Cinnamomi(OC), volatile oil of cassia bark, on mice viral myocarditis caused by coxsackie virus B3m(CVB3m). METHODS: Male BALB/c mice were randomly divided into 6 groups: 1 control group (n=16)treated with normal saline i.p, 1 model group (n=30) treated with normal saline, 1 RA group (n=30) treated with 50 mg/kg Radix astragali injection i.p. as positive control and 3 treatment groups (30 in each group) respectively given 49.1, 36.7 and 26.5 mg/kg OC after 72 h viral inoculation. Except for the control group, the other 5 groups were all inoculated with CVB3m i.p. and were bred in insulation lab. After one week treatment, the death rate, the heart histopathologic changes, the content of CK, CKMB and LDH in mice serum, and MAD and SOD in myocardium were observed. RESULTS: The death rate, the histopathologic score, the content of CK and CKMB in mice serum and MAD in myocardium were lower and the activities of SOD were higher in 49.1 and 36.7 mg/kg OC groups than in model group (P<0.05). The death rate was lower (P<0.05) and the histopathologic changes (necrosis, degeneration and cellular infiltration) were milder in OC groups than in model group at 21 d after viral inoculation. CONCLUSION: OC has a significant therapeutic effect on treatment of viral myocarditis caused by CVB3m. ......
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