Effect of monoclonal antibody to integrin §Ñv¦Â3 on adherent ability of eutopic endometrium cells in women with ndometriosis

    ZHAO Jun, LI Yaª²Li, ZONG Liª²Li

    Department of Gynaecology and Obstetrics, PLA General Hospital, Beijing 100853, China

    ¡¾Abstract¡¿ AIM: To explore the effect of monoclonal antibody to integrin av¦Â3 on the adherent ability of eutopic endometrium cells in women with endometriosis. METHODS: The cells from eutopic endometrium of women with endometriosis were cultured in 96ª²well plates. The effect of Lm609 and 7E3, two monoclonal antibodies to integrin av¦Â3, on the adherent ability of endometrium cells at different concentrations was examined with the MTT assay. The experiments at each concentration were repeated three times for each case. RESULTS: The monoclonal antibody to integrin av¦Â3 had greater effects on the adherent ability of eutopic endometrium cells in the experimental groups than those in the control group, with no significant difference between different concentrations. CONCLUSION: Lm609 and 7E3, the monoclonal antibodies to integrin av¦Â3, can inhibit the adherent ability of endometrium cells and may thus inhibit the formation of endometriosis. ......