【摘要】 目的：比较西酞普兰与帕罗西汀治疗抑郁症的疗效及安全性。方法：82例符合CCMD-3抑郁症诊断标准的患者，随机分配用西酞普兰和帕罗西汀治疗，疗程6周，用汉密尔顿抑郁量表(HAMD)评定临床疗效，副反应量表(TESS)评定不良反应。 结果：西酞普兰组显效率63.4%，有效率83%，帕罗西汀组为63.4%；78%，疗效相当，差异无显著性。两组不良反应轻微。结论：西酞普兰和帕罗西汀抗抑郁疗效肯定，不良反应轻。

    【关键词 】 西酞普兰；帕罗西汀；抑郁症

    A Comparative study of citalopram and Paroxetine in the treatment of depression

    LI Da-shun, WANG Chun-lan, YU Jian-xin.

    (Second people's hospital of Dezhou, Shandong 253022, China)

    【Abstract】 Objective：To compare the efficacy and side effects of citalopram and Paroxetine in the treatment of depression. Methods:82 patients who met CCMD-3 criteria for depression were randomly assigned to citalopram group and Paroxetine group. The Period of study was 6 weeks. The efficacy was rated with Hamilton Depression Rating Scale(HAMD),and the side effects were rated with Treatmend Emergent symptoms scale (TESS).Results: Total clinical effective rate and response rate Was 63.4% and 83% for Citalopram group, 63.4% and 78% for Paroxetine group after 6 Weeks repectively. There Were no significant differences on clinical efficacy between 2 groups. Conclusions: Citalopram and Paroxetine is effective antidepressants with fewer side effects. ......