骨肉瘤_____骨肉瘤;MAPK信号通路;细胞凋亡;

阿霉素可通过MAPK信号转导通路促进成骨肉瘤细胞凋亡

http://www.100md.com 《第四军医大学学报》 2005年第12期

骨肉瘤,,骨肉瘤;MAPK信号通路;细胞凋亡;,阿霉素,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Study on the molecular mechanisms of osteosarcoma cell apoptosis induced by Adriamycin

    ZHENG LianHe1,ZHANG Wei2，HAN Tao1，MA BaoAn1，FAN QinYu1

    1Department of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xian 710038,China, 2Department of Microbiology，School of Basic Medicine，Fourth Military Medical University, Xian 710033，China

    【Abstract】 AIM: Based on osteosarcoma cell lines,to study the molecular mechanisms of osteosarcoma cell apoptosis by appropriate density and actiontime of Adriamycin. METHODS: Firstly,depanding on the methods of FCM，MTT etc,we got the best density and actiontime of adriamycin.and then,we used several depressors of different signal transduction pathways to observe the possible pathway of osteosarcoma cell apoptosis.Finally, we observed different expression including phosphorylation and non phosphorylation of correlated signal molecules,by the methods of WesternBlot. RESULTS: We got optimal density(04 mg/L) and actiontime(12 h )of adriamycin; and found that MAPK pathway had something with osteosarcoma cell apoptosis; finally, we demonstrated that several signal molecules participated in MAPK pathway .CONCLUSION: The osteosarcoma cell apoptosis resulting from adriamycin might be relative to MAPK pathway. ......

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