抗心磷脂抗体_____骨坏死；_SARS；

严重急性呼吸系统综合征后骨坏死与抗心磷脂抗体

http://www.100md.com 《中国矫形外科杂志》 2006年第7期

抗心磷脂抗体,,骨坏死；,SARS；,抗心磷脂抗体,1材料与方法,2讨论,参考文献：

     摘要：[目的]测定严重急性呼吸系统综合征(severe acute respiratory syndrome，SARS)后骨坏死患者的抗心磷脂抗体，探讨SARS后骨坏死的病因学，以便用于非创伤性骨坏死的早期诊断和易感人群的筛选。[方法]取62例SARS后骨坏死患者抽取空腹肘静脉血，另取健康人群52名为对照，应用酶联免疫吸附法测定抗心磷脂抗体的IgA、IgG和ISM，并检测血浆凝血酶原时间(PT)和凝血酶时间(TT)，凝血酶原活动度(PTA)和国际标准化值(INR)4项常规出凝血检查。[结果]SARS后骨坏死患者抗心磷脂抗体阳性者多见。骨坏死组62人中有21人出现抗心磷脂抗体阳性，占339%，其中IgA(1133±11209)APL，IgG(5127±5927)GPL,IgM(17821±10606)MPL。对照组52人中仅有4人出现异常，占77%，其中IgA(10702±3126)APL，IgG(5184±4780)GPL，IgM(14684±5516)MPL，经独立样本t检验和卡方检验处理，两组之间有显著性差异(P<005)。血浆凝血酶原时间(PT)和凝血酶时间(TT)，凝血酶原活动度(PTA)和国际标准化值(INR)4项常规出凝血检查两组之间无显著性差异。[结论]SARS后骨坏死患者的抗心磷脂抗体阳性率增多，抗心磷脂抗体可能在骨坏死发生中起作用。

    关键词：骨坏死； SARS；抗心磷脂抗体

    PostSARS osteonecrosis and anticardiolipin antibodies∥SUN Wei,LI Zirong,SHI Zhencai,et alDepartment of Orthopaedics,ChinaJapan Friendship Hospital,Beijing 100029

    Abstract：[Objective]To explore the correlation between anticardiolipin antibodies and postSARS patients with osteonecrosis,investigate the etiology of postSARS osteonecrosis,and select the sensitive molecular symbols for early diagnosis and distinguish the high risk population[Method]The studied subjects were divided into two groupsSixtytwo postSARS patients with osteonecrosis was one group,and 52 matched healthy people was as normal controlled groupEmpty stomach blood samples from cubital veins were collected from both groupsIgA,IgG and IgM of anticardiolipin antibodies types were examined by ELISA[Result]Twentyone of 62 postSARS osteonecrosis patients were tested at least one type of anticardiolipin antibodies positive,among them,with IgA(1133±11209)APL,IgG(5127±5927)GPL,IGM(17821±10606)MPLFour of 52 control group persons were detected positive,with IGA(10702±3126)APL,IgG(5184±4780)GPL,IgM(14684±5516)MPLThere were significant differences between two groups,while,there were no difference in prothrombin time(PT),thrombin time(TT),prothrombin activity(PTA)and international normalized ratio(INR)[Conclusion]The study indicates an increased positive incidence of anticardiolipin antibodies in postSARS patients with osteonecrosisThis has reflected that anticardiolipin antibodies may play a role in osteonecrosis ......

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