[摘要] 目的 探讨基质金属蛋白酶组织抑制剂-1(TIMP-1)在高血压肾硬化发生及发展过程中作用。方法 利用酶联免疫吸附试验(ELISA)双抗体夹心法，分别对20例原发性高血压、20例高血压肾硬化、20例高血压肾硬化尿毒症病人外周血TIMP-1含量进行检测。结果 高血压肾硬化尿毒症组、高血压肾硬化组血清中TIMP-1的含量均高于原发性高血压组，差异有显著性(F=208.97，q=30.87、22.96，P<0.01);高血压肾硬化尿毒症组血清 中TIMP-1的含量高于高血压肾硬化组，差异有显著性(q=7.95，P <0.01)。结论 TIMP-1含量增高在高血压性肾小球硬化和肾间质纤维化的发生及发展过程中起着重要作用。

    [关键词]基质金属蛋白酶1组织抑制剂;高血压;肾硬化症;酶联免疫吸附测定

    CHANGES OF SERUM TIMP-1 LEVEL IN PATIENTS WITH HYPERTENSIVE NEPHROSCLEROSIS AND ITS SIGNIFICANCE

    HAN XING-TAO ， LIU LI-QIU

    (Department of Health， The First People's Hospital of Qingdao Economic and Technological Development Zone， Qingdao 266555，China)

    [ABSTRACT]Objective To study the correlation of tissue inhibitors of metalloproteinase-1 (TIMP-1) and hypertensive ne- phrosclerosis and to investigate the role of TIMP-1 in the development of the disease.Methods The TIMP-1 levels were deter- mined by enzyme-linked immunoadsorbent assay (ELISA) double-antibody -sandwich method in patients with essential hyperten-sion (EH ......