[摘要] 目的 探讨口腔医用冰(简称口冰)的药理作用，为临床用药提供依据。方法 制备二甲苯致小鼠耳 部炎症、琼脂致大鼠足肿胀急性炎症模型，大鼠琼脂肉芽肿慢性炎症模型，观察口冰对炎症的作用;采用热板法进行小鼠热刺激性疼痛试验，断尾法测定小鼠出血时间，观察口冰对小鼠疼痛及出血时间的影响。结果 口冰局部应用能抑制小鼠耳部肿胀、大鼠足肿胀，抑制大鼠肉芽肿，延长疼痛潜伏期，缩短小鼠出血时间。结论口冰有抗炎镇痛止血作用。

    [关键词]口腔医用冰;炎症;疼痛;药理学

    PHARMACOLOGICAL EFFECTS OF ORAL MEDICAL ICE

    ZHAO YONG-JUAN， LIU ZHAN-TAO， SHAO BO-QIN

    (De-partment of Pharmacology， Qingdao University Medical College， Qingdao 266021， China)

    [ABSTRACT] Objective To study the pharmacological effects of oral medical ice (OMI) and to provide for its evidence for clinical application. Methods The anti-inflammatory effect of OMI was determined on three inflammatory models: swelling of mice ear induced by dimethylbenzene， hind paw edema and back granuloma caused by hypodermic injection of agar in rats. The an- algesic action of OMI was studied by observing the mice's reaction to the heat simulation. The effect of OMI on bleeding time was tested by tail-cutting method. Results OMI inhibited the swelling of mice ear ......