骨肉瘤_____骨肉瘤；_P糖蛋白；

骨肉瘤中P糖蛋白、Survivin的表达与化疗疗效的关系

http://www.100md.com 《中国矫形外科杂志》 2006年第9期

骨肉瘤,,骨肉瘤；,P糖蛋白；,Survivin；,免疫组织化学,摘要,关键词,1材料与方法,2结果,3讨论,参考文献

     摘要：[目的]探讨P糖蛋白、Survivin在骨肉瘤中的表达情况与化疗疗效的关系。[方法]对38例骨肉瘤术前的活检标本用免疫组织化学方法分别检测P糖蛋白、Survivin的表达。[结果]P糖蛋白阳性组化疗有效率低于P糖蛋白阴性组；Survivin过表达组化疗有效率明显低于Survivin弱表达组。经Logistic回归分析，Survivin对化疗疗效的预测价值更大。[结论]骨肉瘤中P糖蛋白、Survivin的表达情况对化疗疗效均有一定的预测价值，其中Survivin更大。

     关键词：骨肉瘤； P糖蛋白； Survivin；免疫组织化学

    Relationship between Pglycoprotein,Survivin expression and chemotherapy outcome in osteosarcomas∥DAI Min,NIE Tao,WAN Xizhen,et alDepartment of Orthopaedics Surgery,the First Affiliated Hospital,Jiangxi Medical College,Nanchang 330006

    Abstract：[Objective]To explore the relationship between Pglycoprotein,survivin expression and chemotherapy outcome[Method]The expressions of Pglycoprotein,and of survivin were examined by the immunohistochemistry in 38 specimens of preoperation biopsy of osteosarecomas[Result]The response rate of the Pglycoprotein positive group was lower than that of Pglycoprotein negative groupThe response rate of the survivin overexpression group was significant lower than survivin was found to be more valuable in predicting chemotherapy results[Conclusion]The expressions of Pglycoprotein,and of survivin are clearly associated with osteosarcomas response to chemotherapy in osteosarecoma and survivin is a more valuable parameter ......

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