骨肉瘤中P糖蛋白、Survivin的表达与化疗疗效的关系
閸忔娊鏁拠宥忕窗骨肉瘤,,骨肉瘤;,P糖蛋白;,Survivin;,免疫组织化学,摘要,关键词,1材料与方法,2结果,3讨论,参考文献
摘 要:[目的]探讨P糖蛋白、Survivin在骨肉瘤中的表达情况与化疗疗效的关系。[方法]对38例骨肉瘤术前的活检标本用免疫组织化学方法分别检测P糖蛋白、Survivin的表达。[结果]P糖蛋白阳性组化疗有效率低于P糖蛋白阴性组;Survivin过表达组化疗有效率明显低于Survivin弱表达组。经Logistic回归分析,Survivin对化疗疗效的预测价值更大。[结论]骨肉瘤中P糖蛋白、Survivin的表达情况对化疗疗效均有一定的预测价值,其中Survivin更大。
关键词:骨肉瘤; P糖蛋白; Survivin; 免疫组织化学
Relationship between Pglycoprotein,Survivin expression and chemotherapy outcome in osteosarcomas∥DAI Min,NIE Tao,WAN Xizhen,et alDepartment of Orthopaedics Surgery,the First Affiliated Hospital,Jiangxi Medical College,Nanchang 330006
Abstract:[Objective]To explore the relationship between Pglycoprotein,survivin expression and chemotherapy outcome[Method]The expressions of Pglycoprotein,and of survivin were examined by the immunohistochemistry in 38 specimens of preoperation biopsy of osteosarecomas[Result]The response rate of the Pglycoprotein positive group was lower than that of Pglycoprotein negative groupThe response rate of the survivin overexpression group was significant lower than survivin was found to be more valuable in predicting chemotherapy results[Conclusion]The expressions of Pglycoprotein,and of survivin are clearly associated with osteosarcomas response to chemotherapy in osteosarecoma and survivin is a more valuable parameter ......
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