HBsAg疫苗冲击树突状细胞联合乙肝免疫球蛋白对慢性乙型肝炎及HBV携带者的疗效
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郑鹏远, 白 蓉, 娄海山, 唐芙爱, 白经修,
乙肝免疫球蛋白;树突状细胞;慢性乙型肝炎,郑鹏远,唐芙爱,白经修,司方明,白蓉,娄海山,琚新,徐建强,通讯作者,Eff
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郑鹏远, 唐芙爱, 白经修, 司方明, 郑州大学第二附属医院消化科 河南省郑州市 450014
白蓉, 郑州大学第五附属医院内科 河南省郑州市 450052
娄海山, 琚新, 徐建强, 许昌市人民医院感染科 河南省许昌市 461000
河南省卫生厅医学创新人才工程项目, No. 2004-45
河南省科技厅科技攻关项目, No. 0324410006
通讯作者: 郑鹏远, 450014, 河南省郑州市经八路2号, 郑州大学第二附属医院消化科. medp7123@yahoo.com
电话: 0371-65261035
收稿日期: 2006-01-10 接受日期: 2006-02-09
Efficacy of HBsAg vaccine-pulsed dendritic cells combined with hepatitis B immunoglobulin in treatment of chronic hepatitis B patients and hepatitis B virus carriers
Peng-Yuan Zheng, Rong Bai, Hai-Shan Lou, Fu-Ai Tang, Jing-Xiu Bai, Fang-Ming Si, Xin Ju, Jian-Qiang Xu
Peng-Yuan Zheng, Fu-Ai Tang, Jing-Xiu Bai, Fang-Ming Si, Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan Province, China
Rong Bai, Department of Internal Medicine, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Hai-Shan Lou, Xin Ju, Jian-Qiang Xu, Department of Infectious Diseases, Xuchang People’s Hospital, Xuchang 461000, Henan Province, China
Supported by Medical Innovation Talent Program of Health Department, Henan Province, No. 2004-45, and the Key Item of Science and Technology Department of Henan Province, No. 0324410006
Correspondence to: Peng-Yuan Zheng, Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, Henan Province, China. medp7123@yahoo.com
Received: 2006-01-10 Accepted: 2006-02-09
Abstract
AIM: To investigate the potential effect of HBsAg vaccine-pulsed dendritic cells (DC) combined with hepatitis B immunoglobulin (HBIg) on chronic hepatitis B (CHB) patients and hepatitis B virus (HBV) carriers.
METHODS: HBsAg vaccine-pulsed DC (106) and HBIg (200 U) were injected into 66 CHB patients once a month, respectively ......
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