婴儿肝炎综合征、胆道闭锁、胆总管囊肿与巨细胞病毒感染的关系
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王宝香, 朱润庆
巨细胞病毒感染;婴儿肝炎综合征;胆道闭锁;胆总管囊肿,王宝香,朱润庆,通讯作者,Relationshipbetweenhumancytome
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王宝香, 朱润庆, 武汉大学医学院, 武汉市儿童医院消化内科 湖北省武汉市 430015
通讯作者: 王宝香, 430015, 湖北省武汉市, 武汉市儿童医院消化内科. deying-lu@163.com
电话: 027-62775984
收稿日期: 2006-03-30 接受日期: 2006-04-22
Relationship between human cytomegalovirus infection and three diseases including infantile hepatitis syndrome, biliary stresia, and choledochal cyst
Bao-Xiang Wang, Ren-Qing Zhu
Bao-Xiang Wang, Ren-Qing Zhu, Medical College of Wuhan University; Wuhan Children’s Hospital, Wuhan 430015, Hubei Province, China
Correspondence to: Bao-Xiang Wang, Wuhan Children’s Hospital, Wuhan 430015, Hubei Province,China. deying-lu@163.com
Received: 2006-03-30 Accepted: 2006-04-22
Abstract
AIM: To explore the relationship between human cytomegalovirus (HCMV) infection and infantile hepatitis syndrome (IHS), biliary atresia, and choledochal cyst.
METHODS: The blood and urine samples from children with IHS (n = 98), biliary atresia (n = 50) and choledochal cyst (n = 50), and the blood and breast milk from their mothers were analyzed by enzyme-linked immunosorbent assay (ELISA). Sixty-two subjects without hepatobiliary diseases and their mothers served as controls.
RESULTS: The positive rates of blood CMV-IgM were 61.2% and 33.7% in IHS children and their mothers, 56.0% and 36.0% in biliary atresia children and their mothers, 22.0% and 6.0% in choledochal cyst children and their mothers, and 22.6% and 8.1% in the controls and their mothers, respectively. The positive rates of urine HCMV antigen were 71.4%, 62.0%, 20.0% and 24.2% in IHS, biliary atresia, and choledochal cyst, and control children, while the rates were 91.8%, 82 ......
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