头孢菌素_____7-ADCA；头孢菌素；中间体

7-氨基去乙酰氧基头孢烷酸的合成研究

http://www.100md.com 《广东药学院学报》 2002年第2期

头孢菌素,,7-ADCA；头孢菌素；中间体,1实验部分,2结果与讨论,参考文献

     摘要 7-氨基去乙酰氧基头孢烷酸(7-ADCA)是头孢菌素合成的重要中间体，一般以青霉素为原料，经氧化，扩环-重排，裂解三步反应制备。本文研究用ρ=20%过氧乙酸作氧化剂，反相HPLC监测扩环-重排反应，酰化酶反应裂解的方法。该工艺先进，反应温和，收率高，适合于工业化规模生产。

    关键词 7-ADCA；头孢菌素；中间体

    Abstract 7-aminodeacetoxy cephalosporanic acid (7-ADCA) is a intermediate for cephalosporin, it is prepared from penicillin, via oxidation reaction, ringenlargement and rearrangement reaction and enzymolysis. In this study,20% peroxyacetic acid was used for oxidation, reversion phase HPLC was used to monitor and control ringenlargement and rearrangement reaction,and acylase for hydrolysis to prepare 7-ADCA. This advanced technique was operated under mild condition, with high yield and suitable for industrial production.

    Key words 7-ADCA, cephalosporin, intermediate.

    1963年 ......

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