免疫治疗_____共刺激；TCRVβ基因；免疫治疗

共刺激信号在抗肝脏肿瘤免疫中作用的研究

http://www.100md.com 《广东药学院学报》 2002年第1期

免疫治疗,,共刺激；TCRVβ基因；免疫治疗,1实验部分,2结果和讨论,3结论,参考文献

     摘要目的：研究共刺激信号在抗肝脏肿瘤免疫中作用。方法：分析经antiCD3McAb和antiCD28McAb协同共刺激，并与肝脏肿瘤细胞(HepG2-2215细胞株)共同孵育的人外周血淋巴细胞(PBLs)。结果：发现其TCRVβ基因表达呈限制性，初步筛选出识别肝脏肿瘤抗原的TCRVβ基因亚家族。结论：有针对性地在体外大量扩增表达Vβ3、Vβ14的T细胞并回输给该肝脏肿瘤患者，可能比非特异性的LAK或CD3AK更有疗效。

    关键词共刺激；TCRVβ基因；免疫治疗

    Study on the effect of costimulation in antiliver tumor immune

    LI Yina HUANG SHUlin, LUO Liqiong

    (Guangdong College of Pharmacy, Guangzhou, Guangdong 510224)

    Abstract The expression of TCRVβ genes in peripheral blood lymphocytes (PBLs) costimulated by antiCD3McAb and antiCD28McAb and incubated with hepatocellular carcinoma (HCC) cell line (HepG2-2215) were analyzed. The result indicated a restricted TCRVβ usage in HCC.The TCRVβ gene subfamilies recognizing liver tumor antigens were screened.

    Key words costimulation; TCRVβ gene; immune therapy

    在抗肿瘤免疫中 ......

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