长链甘油三酸酯_

中长链脂肪乳注射液制备工艺研究

http://www.100md.com 《广东药学院学报》 2001年第3期

长链甘油三酸酯,,长链甘油三酸酯；中链甘油三酸酯；脂肪乳；正交试验,1处方,2乳化工艺优化实验,3制备工艺,4制备工艺的验证,5保证产品质量的其他相关措施,6讨论

     摘要目的：探讨中/长链脂肪乳注射液和制备工艺。方法：用正交试验法选用L9(34)正交表优选工艺条件。结果：制备的样品25 ℃放置18个月各项指标符合规定。结论：制备工艺可行。

    关键词长链甘油三酸酯；中链甘油三酸酯；脂肪乳；正交试验

    Study on the preparation technology of medium and longchain triglyceride fat emulsion injection

    Abstract Objective：To explore the preparative technology of medium and longchain triglyceride fat emulsion injection. Method：The preparing factors were optimized by orthogomal design. Results： Samples of products were stored at 25 ℃ for 18 months and conformed to the standards. Conclusions：The method is reliable.

    Key words mediumchain triglycerides; longchain triglycerides; fat emulsion injection; orthogomal design.

    脂肪乳剂是肠外营养的重要组成部分，是能量的补充剂。临床上，脂肪乳剂除了提供机体代谢所需的能量外，还为机体提供生物膜和生物活性物质代谢所需的多不饱和脂肪酸，防止和纠正机体必需脂肪酸的缺乏。目前，临床上常用的脂肪乳剂是长链甘油三酸酯(LCT)脂肪乳剂，基本处方是以大豆油(LCT)为主要成分，用精制卵磷脂作为乳化剂，用甘油作为等渗剂 ......

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