酮康唑_____酮康唑；微囊；制备；含量测定

酮康唑微囊的制备与含量测定

http://www.100md.com 《广东药学院学报》 2001年第4期

酮康唑,,酮康唑；微囊；制备；含量测定,1仪器与试剂,2方法与结果,3讨论,参考文献

     摘要目的: 制备酮康唑微囊,提高酮康唑的稳定性。方法：以明胶-阿拉伯胶作为囊材，用复凝聚法制备酮康唑微囊，采用紫外分光光度法直接测定酮康唑含量。结果：制剂平均体积径为7.99 μm，在质量浓度范围0.05～0.15 mg/mL内吸收度与浓度间线形关系良好(回归方程为A=2.3967C+0.0595 ，r=0.9996,n=5),平均回收率为104.67%±0.76% (n=3)，日内差、日间差测定结果证明在室温下产品稳定，平均包封率为37.37%±0.26%(n=3)。结论:所得产品均匀、稳定，含量测定方法简便可靠。

    关键词酮康唑；微囊；制备；含量测定

    Preparation and Determination of the Microcapsules of Ketoconazole

    SHANG Beicheng,XU Guili,ZHANG Qing,TANG Bing,LIU Tao

    (Kunming General Hospital of Chengdu Military Command,Kunming,China 650032)

    Abstract Objective: To prepare the microcapsules of ketoconazole and improve its stability . Methods: Using gelatinacacia gum as the sealing material and with the method of phase separationcoacervation,the microcapsules of ketoconazole were prepared. The content of ketoconazole was determined by UV spectrophotometry .Results: The average volume size of the microcapsules was 7.99μm. The excellent linear relationship was obtained within the range of 0.05～0.15 mg/mL(r=0.9996,n=5).The average recovery was 104.67%±0.76% (n=3).The entrapment efficiency was 37.37%±0.26%(n=3). Conclusion The design of the preparation was reasonable. The method for determination was simple,reliable and reproducible. ......

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