二乙酰基吡啶_

2，6二乙酰基吡啶合成方法的改进

http://www.100md.com 《广东药学院学报》 2001年第3期

二乙酰基吡啶,,2，6二乙酰基吡啶；化学合成；有机配体,1实验部分,2讨论,参考文献

     摘要报道对2，6二乙酰基吡啶合成方法的改进。改进内容及结果：①改用铬酐代替高锰酸钾作为氧化剂，产率为77%(文献值64%)；②改用β萘磺酸作为催化剂代替干燥的氯化氢，产率为81%(文献值572%)；③改进新蒸的二甲苯为溶剂，得到最终产品，产率为74%(文献值55%)。本合成方法可使各步骤产率有所提高。

    关键词 2，6二乙酰基吡啶；化学合成；有机配体

    An improved method for the preparation of 2,6diacetylpyridine

    Abstract A modified method to synthesize 2,6diacetylpyridine was reported.It was shown that:①Taking chromic acid anhydride as oxidant instead of potassium permanganate,the productive efficiency was 77%(64%in literature).②Using βnahtholsulfonic acid to replace dry hydrogen chloride as catalyst,the productive efficiency was 81%(57.2%in literatuer).③Using freshly distilled xylene as the solvent to prepare the end product,the productive efficiency was 74%(55%in literature).

    Key words 2.6diacetylpyridine;chemical synthesis;organic ligand

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