应用WEIBULL分布函数建立非房室线性药动学模型
非房室线性药动学,,Weibull分布函数;非房室线性药动学,1模型的建立,2模型的拟合,3讨论,参考文献
摘 要 运用系统控制过程的卷积公式及WEIBULL分布函数导出浓度时间关系,然后应用单纯形改良法拟合,在实验给定误差范围内得到一组最优参数和一条最优曲线。与传统的房室模型拟合出的曲线比较,可以更好的拟合多峰血药浓度时间曲线。关键词 Weibull分布函数;非房室线性药动学
Establishment of a noncompartment linear model using WEIBULL distribution function
ZHENG Chuanqi,YANG Jing,WEI XueFang(Guangzhou Municipal Institute for Drug Control, Guangzhou, Guangdong 51016)
Abstract Convolution formula and weibull distribution function were used to deduce concentrationtime function and modified simple shape law was used to optimized a set of suitable parameter and a appropriate curve within a minimum given error. This model has obvious advantage compared with traditional compartment model.
Key words weibull distribution;noncompartment linear model.
受药物性质或体内吸收特点的影响 ......
您现在查看是摘要页,全文长 4526 字符。