精氨酸甘草次酸__(期刊论文)

精氨酸甘草次酸的制备及核磁共振谱分析

http://www.100md.com 《分析化学》 2006年第5期

精氨酸甘草次酸,,精氨酸甘草次酸，甘草次酸，精氨酸，核磁共振谱，碳氢信号全归属,摘要,关键词,1引言,2实验部分,3结果与讨论,References

     摘要

    以18β甘草次酸为原料，合成了一种新的甘草次酸盐类衍生物——精氨酸甘草次酸，利用1H NMR、13C NMR、DEPT、1H1H COSY、HMQC、HMBC等1D和2D NMR技术对其碳和氢质子信号进行了全归属，并通过与两种原料化合物核磁共振谱数据的对比，揭示了该成盐反应的作用机制和产物的结构类型。

     关键词 精氨酸甘草次酸，甘草次酸，精氨酸，核磁共振谱，碳氢信号全归属

    Study on Preparation of ArginineGlycyrrhetinic Acid and Structure Analysis by 1D and 2D Spectra of Nuclear Magnetic Resonance

    Xu Hui*1,2, Liu Shengsheng3, Jiang Yongtao2,3, Liu Ke2,3, Wang Zhengtao1

    (Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Institute ofChinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203)

    (College of Pharmacy, Yantai University, Yantai 264005)

    (Shandong Engineering Research Center for Natural Drugs, Yantai 264005)

    Abstract A new derivative of glycyrrhetinic acid, arginineglycyrrhetinic acid, was synthesized by the reaction of 18βglycyrrhetinic acid with Larginine. 1H NMR (nuclear magnetic resonance), 13C NMR, distorsionless enhancement by polarization transter (DEPT) and a series of 2D NMR techniques, including heteronuclear multiple quantrum correlation (HMQC), heteronuclear multiple bond correlation (HMBC) and 1H1H correlation spectrometry (COSY), were applied to assign all carbon and proton signals of the product. Moreover, the mechanism of this reaction and the bond type yielded between the two reactants were studied by comparing the NMR data of product and those of reactants. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/06/20/01/41/22.htm

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