原发性脾脏恶性淋巴瘤21例的临床分析
脾脏；淋巴瘤；脾切除术,,脾脏；淋巴瘤；脾切除术,【摘要】,【关键词】,1资料与方法,2结果,3讨论,【参考文献】
【摘要】 目的 研究原发性脾脏恶性淋巴瘤(SPL)的临床和病理特征与治疗方法。方法 对1975～2000年收治的21例原发性脾脏恶性淋巴瘤患者的临床资料进行回顾性分析。结果 21例均行手术治疗，14例行COP或CHOP方案化疗，7例未行化疗，术后5年生存率分别为35.7%和28.6%。21例均为术后病理确诊，其中B细胞源性20例，T细胞源性1例。按Ahman脾恶性淋巴瘤临床分期，Ⅰ期9例，Ⅱ期7例，Ⅲ期5例，5年生存率分别为55.6%、42.9%、20%。结论 原发性脾脏恶性淋巴瘤的诊断主要依靠B超和CT，病期的早晚影响其预后，手术治疗联合化疗是本病的主要治疗方法。【关键词】 脾脏；淋巴瘤；脾切除术
Primary lymphoma of the spleen:clinical analysis of 21 cases
DENG Liang,XU Fengfeng,ZHEN Yuyang.Department of General Surgery,Huangpu Division,The First Affiliated Hospital,Sun Yatsen University,Guangzhou 510700,China
【Abstract】 Objective To describe the clinical,pathological features,and treatment of primary lymphoma of the spleen.Methods Clinicopathologic features of 21 patients treated from 1975 to 2000 were analyzed retrospectively.Results All patients underwent resection of the tumor.14 patients accepted chemotherapy after operation.The 5year survival rates were 35.7% and 28.6%.21 patients were confirmed pathologically.Bcell type nonHodgkins lymphoma was noted in 20 patients and Tcell in 2.According to Ahmans staging,9 patients belonged to stageⅠ7 stageⅡ,and 5 stageⅢ.The 5year survival rates were 55.6%,42.9%and 20% respectively.Conclusion The diagnosis of splenic lymphoma is dependent mainly on Bultrasound examination and CT scanning.Splenectomy combined with chemotherapy may provide optimum therapy for patients with splenic lymphoma. ......
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