瘢痕疙瘩家系；连锁分析；微卫星标记；易感基因；异质性

中国人群瘢痕疙瘩家系易感基因的定位研究

http://www.100md.com 《第四军医大学学报》 2006年第11期

瘢痕疙瘩家系；连锁分析；微卫星标记；易感基因；异质性,,瘢痕疙瘩家系；连锁分析；微卫星标记；易感基因；异质性,【摘要】,【关键词】,0引言,1对象和方法

     Study on location for keloid susceptible locus in Chinese pedigrees

    CHEN Yang, GAO JianHua, LIU XiaoJun, YAN Xin, SONG Mei

    Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

    【Abstract】 AIM: To locate keloid susceptible locus in Chinese pedigrees. METHODS: Peripheral venous blood samples from 51 members in 2 large keloid pedigrees were collected for extracting genomic DNA. Six markers on chromosome 2q23 were selected as microsatellite markers according to recent foreign literatures on the similar study. Subsequently, these markers were amplified by PCR, and all PCR products were genotyped and the linkage analyses were performed. RESULTS: Most of the twopoint LOD scores for these markers at θ=0 were less than -2, which excluded the linkage. CONCLUSION: The keloid susceptible locus in Chinese pedigrees were not on chromosome 2q23.

    【Keywords】 keloid pedigree; linkage analysis; microsatellite marker; susceptibility genes; heterogeneity

     【摘要】 目的：定位中国人群瘢痕疙瘩家系的易感基因. 方法：选择2个中国人群瘢痕疙瘩大家系 ......

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