摘要：目的：雷贝拉唑钠10mg/d在消化性溃疡治疗中的疗效及安全性，并与奥美拉唑20mg/d进行比较。方法：采用随机开放对照临床研究。将消化性溃疡患者随机分为四组。A组：口服雷贝拉唑钠片每次10mg；B组：口服奥美拉唑胶囊每次20mg，每日1次；C、D组：在A、B两组基础上分别睡前加服雷尼替丁150mg。结果：四组患者平均胃内ph值，平均中位ph值，夜间平均胃内ph值、夜间平均中位ph值及症状积分下降率比较：C组和D组明显优于A组和B组；A组、B组之间，C组、D组之间无差异。整个试验过程中四组不良反应率分别为2.3%、2.6%、3.3%、3.1%，不良反应发生率相似。结论：雷贝拉唑钠10mg能安全、有效地治疗消化性溃疡，其缓解症状、抑制胃酸的疗效与奥美拉唑20mg相当。

     关键词：雷贝拉唑钠；消化性溃疡；质子泵抑制剂；H2受体拮抗剂

    The Clinical Observation of Rabeprazole Sodium in Peptic Ulcer Treatment

    XU Yi,GAN Ya-jiao,YU Xiao-xia

    (Suixi People’s Hospital, Guangdong Suixi 524300, China)

    Abstract： Objective： To evaluate the effect and safety of Rabeprazole Sodium 10mg/d in peptic ulcer treatment comparing with omeprazole 20mg/d. Method： Patients with peptic ulcer were randomly divided into four groups. A group took Rabeprazole Sodium 10mg/d, B group took Omeprazole 20mg/d, C and D groups each took Ranitidine 150mg q.n in the base of A and B. Result： The compare of average gastric ph, average median ph, average gastric ph at night, average median ph at night and decline rate of symptom integral in the four groups: C and D groups were superior to A and B groups, while there were no difference between A and B, or C and D. The side effect rate of the four groups were 2.3%、2.6%、3.3%、3.1%. They were similar. Conclusion： Rabeprazole Sodium 10mg/d in peptic ulcer treatment were effective and safety, and the effects of easing symptoms, antagonizing gastric acid were similar to Omeprazole 20mg/d. ......