三联疗法对非糜烂性反流病合并H pylori感染患者预后的影响
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朱金水, 宋明全, 朱 励, 王 龙, 陈金联,
三联疗法;Hpylori根除;非糜烂性反流病;疗效,三联疗法对非糜烂性反流病合并Hpylori感染患者预后的影响,朱金水,宋明全,朱励,王龙,陈金联,达炜,孙群,王如华,通讯作者,Efficacyof
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朱金水, 宋明全, 朱励, 王龙, 陈金联, 达炜, 孙群, 王如华, 上海交通大学附属第六人民医院消化科 上海市 200233
通讯作者: 朱金水, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化科. zhujs1803@hotmail.com
电话: 021-64369181-8969 传真: 021-64837019
收稿日期: 2006-03-20 接受日期: 2006-05-08
Efficacy of triple therapy and its effect on prognosis of H pylori infected patients with non-erosive reflux disease
Jin-Shui Zhu, Ming-Quan Song, Li Zhu, Long Wang, Jin-Lian Chen, Wei Da, Qun Sun, Ru-Hua Wang
Jin-Shui Zhu, Ming-Quan Song, Li Zhu, Long Wang, Jin-Lian Chen, Wei Da, Qun Sun, Ru-Hua Wang, Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
Correspondence to: Jin-Shui Zhu, Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, China. zhujs1803@hotmail.com
Received: 2006-03-20 Accepted: 2006-05-08
Abstract
AIM: To investigate the efficacy of triple therapy and the effect of H pylori eradication on the prognosis of patients with non-erosive reflux disease (NERD).
METHODS: One-hundred and twenty H pylori infected patients with NERD were randomly and averagely divided into group A and B. The patients in group A received triple therapy (20 mg Losec plus 500 mg Clarithromycin plus 500 mg Amoxicillin, twice a day) for 1 wk, and the ones in group B served as the controls (treated with 20 mg Losec twice a day). From week 2, the patients, whose symptoms of non-erosive reflux disease were alleviated, in both groups were orally treated only with 20 mg Losec once a day until the end of week 3. Gastric endoscopy and 13C breath test were performed at the end of 12 mo.
RESULTS: 13C breath test showed that the rate of H pylori eradication was significantly higher in group A than that in group B (95% vs 8.3%, P < 0.01). The degrees of corpus atrophy and intestinal metaplasia were also markedly alleviated in group A (P < 0 ......
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