祁春梅 武维恒 李莉 彭城 甘军民 蔡文标 刁军 陆远

    摘要 目的:通过快速床旁检测心力衰竭(HF)患者血浆脑钠素(BNP)水平，监测血管紧张素转换酶抑制剂(ACEI)药物的治疗心力衰竭的疗效，BNP对心力衰竭患者早期诊断、预后评价的价值。方法: 入选2003年8月-2005年12月HF患者170例，随机分为实验组和对照组，入院后即刻床边抽取静脉血测血浆BNP水平并行心脏超声检查，检测用药前后3个月的射血分数(EF)、 BNP含量，观察出院后三个月内不良事件的发生。结果: 实验组应用ACEI治疗3月后 BNP水平下降(865.32±398.64 vs 131.32±165.01, P<0.001)；EF 值升高(37.54±14.09 vs 46.02±10.32,P<0.05)；BNP浓度严重升高患者，死亡率及再住院率明显升高。结论：快速床旁边检测血浆中BNP水平是评价ACEI疗效的有效指标；血浆BNP水平高低是对心衰患者进行预后评价的一项重要指标。

    关键词 脑钠素 ACEI 心力衰竭 预后

     The Value of Rapid Bedside Measurements of BNP on the Treatment of ACEI and Prognosis in Patients with Heart Failure

     Qi chunmei Wu weiheng LI li et al

    .(Department of Cardiology of the Second Affiliated Hospital, Xuzhou Medical College, Jiangsu 221006)

     Abstract Objective:To assess the value of rapid bedside measurements of BNP on on the treatment of ACEI and Prognosis in Patients with Heart Failure .Methods: 170 patients with heart failure which were divided into two groups randomly were enrolled from Aug 2003～Dec 2005. The rapid bedside measurements of BNP and echocardiography were performed before the treatment of ACEI and three months later , adverse cardiac events within three months after discharge were recognized. Result: Serum BNP concentration declined after 3 months treatment of ACEI in experimental group(865.32±398.64 vs 131.32±165.01, P<0.001)；EF value increased(37.54±14.09 vs 46.02±10.32,P<0.05).The mortality and rehospitalization rate of the patients,whose serum BNP concentration obviously rised, had increased significantly.Conclusion: Serum BNP concentration is an important marker to evaluate the treatment of ACEI and prognosis in patients with heart failure. ......

    百拇医药网 http://www.100md.com/html/DirDu/2006/07/10/02/56/56.htm

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