摘要：目的测定4个不同厂家(分别以A，B，C，D，表示)芒果止咳片的体外溶出度，为评价和控制药品质量提供参数与依据。方法按《中国药典》2000年版进行，以蒸馏水为释放介质，用紫外分光光度法在259 nm波长处测定紫外吸收度；使用SPSS一般线性模型(General Liner Model)对不同厂家芒果止咳片的体外溶出度进行多重比较。结果厂家A，C，D分别与厂家B的溶出度有显著差异(P<0.005)，而厂家A，C与D之间无显著差异(P>0.05)。结论 有必要测定芒果止咳片的体外溶出度。

    关键词：芒果止咳片； 溶出度； 紫外分光光度法； 一般线性模型

    Study on the Dissolubility of Mangguozhike Tablets

    HUANG Xian

    (Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China)

    Abstract：ObjectiveThe dissolution rates of baica1in in Mangguozhike Tablets were determined to provide a basis for evaluating and controlling the drug quality. MethodsThe dissolution rates of Mangguozhike tablets with different batch numbers were determined by UV,using water as disso1ution medium. ResultsThe T50 of Mangguozhike tabletes was 45.57~62.96 min and there were significant differences in dissolution parameters between tablets tested(P < 0. 005).ConclusionIt is suggested that the dissolubility of each batch of products should be tested to control the quality and ensure clinical efficacy. ......