“抗纤汤”治疗四氯化碳致肝纤维化大鼠模型的实验研究
],中药；四氯化碳；大鼠；肝纤维化；模型,1材料与方法,2结果,3讨论,参考文献
[摘 要] 目的 观察“抗纤汤”对四氯化碳致肝损伤的肝纤维化大鼠模型的治疗效果。方法 60只大鼠被随机分为3组，每组20只，在治疗组用“抗纤汤”治疗3个月后分别比较正常对照组、模型组和治疗组大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、Ⅲ型前胶原(PCⅢ)、透明质酸(HA)的含量，并观察其组织学改变的差异。结果 治疗组血清ALT、AST、PCⅢ、HA均显著低于模型组(P<005)。病理学提示，治疗组肝细胞损伤、肝脏脂肪变性与纤维组织形成较少。结论 “抗纤汤”在抗纤维化治疗中有确切疗效。[关键词] 中药；四氯化碳；大鼠；肝纤维化；模型
Study of Kang Xian Soup to prevent liver fibrosis induced by carbon tetrachloride in rats
DING Tilong, MA Yong, YAN Jiachun, et al.The Center of Nanjing Command Liver Disease, the 123th Hospital of PLA, Bengbu 233015, Anhui, China
[Abstract] Objective To study the effect of Kang Xian Soup to prevent liver fibrosis induced by carbon tetrachloride in rats.Methods 60 rats were divided randomly into three groups which were normal control group, model group and treatment group. The levels of serum ALT, AST, PCⅢ and HA were detected and pathologic changes of hepatic tissues were analyzed on the three groups.Results The levels of serum ALT, AST, PCⅢ and HA in the treatment group were notably lower than those of model group (P<005) and the pathologic results under microscope were much better than model group. Hepatocyte damnify, adipohepar and fiber tissues of liver in the treatment group were fewer than model group. Conclusions Kang Xian Soup is an effective drug to prevent liver fibrosis. ......
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