外燥；_桑杏汤；_血清；_呼吸道；_抗体____

桑杏汤对温燥小鼠血清与呼吸道抗体的影响

http://www.100md.com 《时珍国医国药》 2006年第6期

外燥；,桑杏汤；,血清；,呼吸道；,抗体,,外燥；,桑杏汤；,血清；,呼吸道；,抗体,摘要,关键词,1材料与方法,2结果,3讨论,参考文献

     摘要：目的观察桑杏汤对温燥小鼠血清IgG(IgGS)、呼吸道液IgG(IgGR)与呼吸道黏多糖(RS)的影响。方法54只SPF级昆明小鼠随机分为常温常湿组(A组)、温燥对照组(B组)和温燥治疗组(C组)，每组18只。药物处理后第5天检测IgGS，IgGR，RS(μg/ml)与脾脏及胸腺平均重量(mg)。结果 B组IgGR(2.30±0.32)明显低于A组(5.68±0.64，P<0.01)，C组RS、IgGS明显高于A组，且该组IgGR接近A组，但胸腺平均重量低于其它二组(P<0.01)。结论温燥可致小鼠气道IgGR降低而抵抗力下降；桑杏汤主要作用机理是促进肺津生成而润燥，加之增加气道IgGR，共同增强气道御邪能力。结果还为中药药物归经理论提供实验证据。

    关键词：外燥；桑杏汤；血清；呼吸道；抗体

    Effects on Antibodies of Secretion of Respiratory and Intestine of Mice in WarmDry with "SangXing Tang"

    DING Jianzhong, GONG Quan, ZHANG Liutong, QIU Xingfan, CHEN Gang, ZHU Huiling, ZHANG Yuan

    (1.Medical School of Yangtze University, Jingzhou 434000,China; 2.Hubei College of Traditional Chinese Medicine,Wuhan 430061, China)

    Abstract：ObjectiveTo investigate the effects on IgG in Serum(IgGS) and respiratory(IgGR)and mucus(RS)and weight of spleen and thymus(mg) in WarmDry with "SangXing Tang". Methods54 kunming mice(SPF) were divided into three groups including group A(normal mice),group B(control mice),group C(cure mice),18 mice/group.RS(μg/ml),IgGS,IgGR and weight of spleen and thymus(mg) were measured on day 5 after treated with the herbs.ResultsIgGR of group B(2.30±0.32) was obviously lower than those of group A(5.68±0.64,P<0.01);RS,IgGS of group C were higher than that of group B(P<0.01) and IgGR was not different significantly with that of group A(P>0.05).ConclusionThe results were first provided evidences that the mechanism of "SangXing Tang" were greater stimulated RS and IgG-R to protected the defend function of respiratory in Warm-Dry. ......

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