p21WAF_CIP1；MDM2；p53；子宫颈癌_

p53、p21WAF/CIP1和MDM2在子宫颈鳞状细胞癌中的表达及意义

http://www.100md.com 《新疆医科大学学报》 2006年第6期

p21WAF,CIP1；MDM2；p53；子宫颈癌,,p21WAF,CIP1；MDM2；p53；子宫颈癌,摘要,关键词

     摘要：目的: 探讨p53、p21WAF/CIP1和MDM2蛋白在子宫颈鳞癌中的表达及其相互关系。方法: 采用免疫组织化学方法研究在43例子宫颈癌、20例子宫颈上皮内瘤变(CIN)、15例正常组织中p53、p21WAF/CIP1及MDM2的表达情况。结果: p53、p21WAF/CIP1及MDM2在43例子宫颈癌中阳性率分别为34.88%、30.23%、25.58%，在20例CIN中的阳性率分别为5%、60%、15%，在正常组织中未见阳性表达, p53、p21WAF/CIP1在3种不同组织间的表达差异有统计学意义(P<0.05)，MDM2在3种不同组织间的表达差异无统计学意义(P>0.05)。p21WAF/CIP1蛋白表达与p53有关(P<0.05)，MDM2蛋白表达与p53无关(P>0.05)。结论: p21WAF/CIP1蛋白表达与p53有关，是子宫颈癌发生的早期事件，MDM2蛋白表达与p53无关。

     关键词：p21WAF/CIP1；MDM2；p53；子宫颈癌

    Expression and significance of p53, p21WAF/CIP1 and MDM2 in cervical squamous cell carcinoma

    SHI Yonghua, Lalai·Suzuke

    (Department of Pathology, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: To determine expression of p53, p21WAF/CIP1 and MDM2 in cervical squamous cell carcinoma and relation between them. Methods: Immunohistochemistry was used to detect p53, p21WAF/CIP1 and MDM2 proteins in 43 cases of cervical cancer, 20 cases of CIN and 15 cases of normal group. Result: The positive rates of p53, p21WAF/CIP1 and MDM2 in 43 cases of cervical cancer were 34.88%, 30.23%, 25.58%. The positive rates of p53, p21WAF/CIP1 and MDM2 in 20 cases of CIN were 5%, 60%,15%, respectively. p53, p21WAF/CIP1 and MDM2 proteins were not detected in 15 cases of normal group. The differences of p53 and p21WAF/CIP1 among the there groups were significant (P<0.05). The difference of MDM2 expression among the there groups was not significant (P>0.05). Expression of p21WAF/CIP1 was correlated with p53 (P<0.05). Expression of MDM2 was not correlated with p53 (P>0.05). Conclusion: The expression of p21WAF/CIP1 was related to p53, p21WAF/CIP1 was an early event in the carcinogenesis of uterine cervix. The expression of MDM2 is not related to p53. ......

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