不孕症；衣原体；抗精子抗体_

不孕女性中衣原体感染与抗精子抗体关系研究

http://www.100md.com 《新疆医科大学学报》 2006年第6期

不孕症；衣原体；抗精子抗体,,不孕症；衣原体；抗精子抗体,摘要,关键词,1资料和方法,2结果,3讨论,参考文献

     摘要: 目的：研究不孕女性中衣原体(chlamydia trachomatis,CT)感染与抗精子抗体(antisperm antibody,AsAb)之间的关系。方法：选择2004年2月～2006年2月在计划生育指导所生殖医学门诊就诊的不孕女性370例,其中原发不孕120例(原发不孕组),继发不孕250例(继发不孕组)，同时选择健康已孕女性100例作为对照(对照组)。应用衣原体一步免疫层析法检测CT感染,酶联免疫吸附法检测血清中AsAb。结果：不孕组CT感染率、AsAb阳性率与对照组比较差异均有统计学意义(P<0.05)；继发不孕组CT感染率、AsAb阳性率与原发不孕组比较差异无统计学意义 (P>0.05)；不孕组中AsAb阳性患者CT感染率与阴性患者比较差异有统计学意义(P<0.05)。结论：CT感染及AsAb均可造成女性不孕, AsAb的产生与CT感染有关。

     关键词：不孕症；衣原体；抗精子抗体

    The relationship of chlamydia trachomatis infection with antisperm antibodies in infertile women

    CHEN Hongxiang， Mayinuer·Niyazi， BAI Shengbin， et al

    (Department of Gynecological Oncology, People′s Hospital of Xinjiang Uygur Autonomous Region，Urumqi 830000, China)

    Abstract: Objective: To investigate the relationship between chlamydia trachomatis (CT) infection and antisperm antibody (AsAb) in infertile women. Methods: From February 2004 to February 2006, a descriptively retrospective study, on 370 infertile women were involved, in which 120 cases were primary infertility and 250 cases were secondary infertility. One hundred health pregnant women were involved in control group. CT of cervical secretion were detected with cultivation and immunochromatographic methods. The serum AsAb was detected with ELISA. Results: The statistical analysis showed that the positive rates of CT and AsAb in infertile group were higher than those in control group (P<0.05). The positive rates of CT, AsAb showed no difference between primary and secondary infertility (P>0.05). The positive rates of CT in infertility patients of positive AsAb were higher than those in negative patients (P<0.05). Conclusions: Infection of CT and AsAb all can induce female infertilily. The production of AsAb may be related to the infection of CT. ......

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