慢性肝病甲胎蛋白升高与原发性肝癌相关研究
慢性肝病；甲胎蛋白；原发性肝癌；鉴别诊断,,慢性肝病；甲胎蛋白；原发性肝癌；鉴别诊断,【摘要】,【关键词】,1资料与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨慢性肝病甲胎蛋白升高与原发性肝癌的相关性。 方法 对144例慢性肝病患者甲胎蛋白进行定量监测，前2m内每15d检查1次，2m后，2～6m进行肝功能、甲胎蛋白、肝胆B超检查，必要时行肝脏CT检查，随访6年。 结果 108例慢性肝炎患者中2例(1.85%)出现恶变，30例肝硬化患者中4例(13.33%)出现恶变；甲胎蛋白动态观察显示：甲胎蛋白一过性升高和持续性低浓度水平无恶变发生，持续性升高恶变率100%(4/4)，反复波动恶变率11.11%(2/18)。 结论 监测慢性肝病甲胎蛋白动态变化，尤其是持续性升高或反复波动者对早期发现原发性肝癌有积极帮助。【关键词】 慢性肝病；甲胎蛋白；原发性肝癌；鉴别诊断
Relativity of AFP increase in chronic hepatopathy and primary hepatocarcinoma
Wei Wei, Lou Zhengtuan
(Panan people's hospital , 322300, Zhejiang, China)
【Abstract】 Objective To explore the relativity of alpha fetoprotein(AFP) increase in chronic hepatopathy and primary hepatocarcinoma(PHC). Methods AFP of 144 patients with chronic hepatopathy were quantitatively monitored, once per 15 days in first 2 months; after 2 months, liver functions, AFP and Bultrasonic examinations of liver and gallbladder were conducted in 2~6 months, if necessary, CT of liver; followup were conducted for 6 years. Results Among 108 patients with chronic hepatitis and 30 with cirrhosis, 2 (1.85%) and 4 (13.33%) respectively exacerbated; dynamic observations of AFP showed that exacerbation didn’t occur when AFP was transient increase and durative low level, rate of exacerbation was 100%(4/4) when durative increase and 11.11%(2/18) when repeated fluctuate. Conclusion Dynamic AFP monitors of patients with chronic hepatopathy especially when AFP is durative increase or repeated fluctuate are helpful to make early diagnosis of the PHC. ......
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