【摘要】 目的 观测营养性肥胖大鼠血浆钙素基因相关肽(CGRP)水平变化以及心脏/体重、肝脏/体重比改变。方法 用特异性放免法测定血浆CGRP含量；称各组大鼠心脏、肝脏湿重，并分别计算与体重之比。结果 肥胖大鼠血浆CGRP水平(77.88±6.84)pg/ml明显低于正常体重大鼠(190.45±35.93)pg/ml(P<0.001); 心脏(g )/体重(g )、肝脏(g )/体重(g )比(0.319±0.019、3.334±0.410)均明显高于普通饲料喂养组(0.225±0.020、2.951±0.730)(P<0.05)。结论 肥胖症大鼠血浆CGRP水平降低，在大鼠肥胖症的发生发展，以及肥胖症大鼠心脏/体重、肝脏/体重比增大中可能起作用。

    【关键词】 肥胖症；降钙素基因相关肽；脂肪

    The changes of calcitonin gene related peptide(CGRP)in nutrition obese rats

    YU Shang-bin，LIU Sheng-yuan，JIN Si，et al.

    Department of Pathophysiology，School of Basic Medical College，Huazhong University of Science and Technology，Wuhan 430030，China

    【Abstract】 Objective To investigate the changed of calcitonin gene related peptide(CGRP)and the rate of fat/weight、 heart/weight and liver/weight in nutritional obese rats.Methods We have determined the contents of CGRP in the animals’ blood plasma by radioimmunoassay(RIA).Results The plasma CGRP level in obesity rats (77.88±6.84)pg/ml was lower than that in normal rats(190.47±35.93)pg/ml(P<0.001) ......