室温离子液体_非那雄胺_溶剂残留(期刊论文)

室温离子液体作溶剂顶空气质联用测定药物中溶剂残留

http://www.100md.com 《分析化学》 2006年第7期

室温离子液体,非那雄胺,溶剂残留,\[bmim\]\[PF6\],顶空气质联用,,室温离子液体，非那雄胺，溶剂残留，\[bmim\]\[PF6\],顶空气质联用,室温离子液体作溶剂顶空气

     摘要 基于室温离子液体无蒸汽压、良好溶解性和分散性的特点，用室温离子液体\[bmim\]\[PF6\]作溶剂顶空气质联用测定非那雄胺中二氯甲烷、三氯甲烷及二氧六环的残留量，优化了顶空气质联用分析条件。二氯甲烷、三氯甲烷及二氧六环的检出限分别为0.2、0.02和0.50 ng, 线性相关系数大于0.99；相对标准偏差 (RSD)0.39%～4.60%；回收率为90.5%～111.9%。室温离子液体作为顶空溶剂的灵敏度有所提高。

     关键词 室温离子液体，非那雄胺，溶剂残留，\[bmim\]\[PF6\], 顶空气质联用

    Room Temperature Ionic Liquid as a Novel Medium for

    the Determination of Solvent Residuals in Drug with

    Headspace Gas ChromatographyMass Spectrometry

    Jiang Hailiang, Shen Haoyu, Le Zhanggao, Zhou Saichun

    (Analysis and Testing Center, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100)

    (Department Applied Chemistry of East China Institute of Technology, Fuzhou 344000)

    Abstract A typical room temperature ionic liquid, 1butyl3methylimidazolium hexafluorophosphate \[bmim\]\[PF6\], was used as an alternative solvent to determine solvent residuals in drug with headspace gas chromatography mass detector(HSGCMS). Injection temperature, equilibrium time and chromatographic condition were optimized. The method was used for the detection of dichloromethane, trichloromethane and dioxane in Finasteride. The detection limits of dichoromethane ......

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