辅酶Q10脂质体在小鼠体内药物动力学和组织分布

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     李喆，邓英杰，杨静文，李宝齐，张修宇，雷国峰

    (沈阳药科大学 药学院，辽宁 沈阳 110016)

    摘要：目的 考察辅酶Q₁₀脂质体静脉给药后在小鼠体内的药代动力学和组织分布。方法 采用乙醇注入法制备辅酶Q₁₀脂质体，静脉注射给药后，HPLC法测定小鼠血浆和组织中辅酶Q₁₀浓度变化。结果 辅酶Q₁₀脂质体的t_1/2和AUC均为溶液剂的1.54倍，辅酶Q₁₀脂质体在心、脾、肺中分布增加，尤以心中增加明显。结论 辅酶Q₁₀脂质体延缓了药物释放，提高了生物利用度，增强了靶向性作用。

    关键词：药剂学；脂质体；乙醇注入法；辅酶Q₁₀；药动学；组织分布

    中图分类号：R94 文献标识码：A

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    Pharmacokinetics and tissue distribution study of CoQ₁₀ liposome in mice

    LI Zhe, DENG Ying-jie, YANG Jing-wen, LI Bao-qi, ZHANG Xiu-yu, LEI Guo-feng

    (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

    Abstract: Objective To evaluate the pharmacokinetics and tissue distribution of CoQ₁₀ in mice after intravenous administration of the CoQ₁₀ liposome. Method The CoQ₁₀ liposome was prepared by ethanol injection method. The plasma concentration and tissue distribution of the drug was determined by HPLC. Results The t_1/2 and AUC of CoQ₁₀ liposome was 1.54-fold higher than that of the CoQ₁₀ solution. The tissue concentration of CoQ₁₀ in heart, spleen and lung, especially in heart after administration of the liposome was higher than those of given CoQ₁₀ solution. Conclusion The CoQ₁₀ liposome exhibits a longer circulation time, higher bioavailability, and better tissue targeting.

    Key word: pharmaceutics; liposomes; ethanol injection; CoQ₁₀; pharmacokinetics; tissue distribution

    http://www.100md.com/html/DirDu/2006/07/19/12/02/92.htm

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