叔丁醇-水共溶剂冷冻干燥工艺及其在药剂学中的应用

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     杜 松¹，左建国²，邓英杰¹

    (1. 沈阳药科大学 药学院, 辽宁 沈阳 110016； 2. 大连理工大学 能源与动力工程学院制冷及低温工程研究所 辽宁 大连 116024)

    摘要：目的 介绍叔丁醇-水共溶剂冷冻干燥工艺及在药剂学研究中的应用。方法 根据国内外相关文献报道，对叔丁醇-水共溶剂冷冻干燥工艺的特点进行了介绍，对其在国内外药剂学研究进展进行了综述。结果与结论 叔丁醇-水共溶剂系统可以作为冷冻干燥的技术平台用于多种制剂的制备。

    关键词：药剂学；冷冻干燥；叔丁醇；共溶剂；

    中图分类号：R94 文献标识码：A

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    Freeze drying using tert-butyl alcohol-water cosolvent and its application in pharmaceutical science

    DU Song¹, ZUO Jian-guo², DENG Ying-jie¹

    (1. School of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016, China; 2. Institute of Refrigeration and Cryogenics, School of Energy and Power Engineering , Dalian University of Technology, Dalian 116024, China)

    Abstract : Objective To introduce the freeze drying process using tert-butyl alcohol (TBA)-water cosolvent system and its application in pharmaceutical science. Methods By summarizing the literature of freeze-drying using tert-butyl alcohol (TBA)-water cosolvent, the properties of this freeze drying process were introduced and the research progress was reviewed. Results and Conclusions Freeze drying using TBA–water cosolvent system can be as a platform and used in many pharmaceutical product.

    Key word : pharmaceutics; freeze-drying; tert-butyl alcohol (TBA); cosolvent

    http://www.100md.com/html/DirDu/2006/07/19/12/05/90.htm

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