尼群地平-β-环糊精包合物的制备
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杨静文, 邓英杰 ,王志宣, 李宝齐
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要： 目的 制备尼群地平-β-环糊精包合物并考察其溶解度和体外溶出度。方法 采用饱和水溶液法制备尼群地平-β-环糊精包合物，并通过差示扫描量热法和红外分析验证。结果 包合物溶解度是尼群地平的8.19倍，溶出速率显著提高。结论 尼群地平经-β-环糊精包合后，能显著提高其溶解度和体外溶出速率。
关键词：药剂学；尼群地平；β-环糊精包合物；溶解度；溶出度
中图分类号: R94 文献标识码：A
contents
Preparation of nitrendipine-β-cyclodextrin complex
YANG Jing-wen, DENG Ying-jie, Wang Zhi-xuan, Li Bao-qi
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To prepare the nitrendipine-β-cyclodextrincomplex and determine its solubility and dissolution characteristics. Methods The inclusion complex of nitrendipine-β-cyclodextrin was prepared by saturated solution method. The differential scanning calorimetric method and IR was used for identification of the complex. Results The solubility of nitrendipine inclused was as 8.19 times as that of the pure drug ,and the dissolution rate was increased greatly. Conclusion The nitrendipine-β-cyclodextrin can improve considerably the solubility and dissolution rate of nitrendipine.
Key words: pharmaceutics; nitrendipine; β-cyclodextrin complex; solubility ;dissolution
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