磷酸苯丙哌林缓释微丸的制备
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陈玉双，邹梅娟，于 杰，杨春光，任君刚，程 刚
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要：目的 制备磷酸苯丙哌林缓释微丸，评价其体外释药特性。方法 采用离心造粒法制备磷酸苯丙哌林微丸，以Eudragit® NE30D 为包衣材料进行包衣，并考察包衣增重、热处理时间等因素对磷酸苯丙哌林缓释微丸体外释药特性的影响。结果 包衣增重为3 %，热处理时间为24 h时，包衣微丸呈现明显的缓释效果，其体外释药特性与国产缓释片基本一致。结论 离心造粒法可用于制备磷酸苯丙哌林缓释微丸。
关键词：药剂学；磷酸苯丙哌林；缓释微丸；离心造粒；Eudragit® NE30D
中图分类号：R 94 文献标识码：A
contents
Preparation of benproperine phosphate sustained-release pellets
CHEN Yu-shuang, ZOU Mei-juan, YU-jie, YANG Chun-guang, REN Jungang, CHENG-gang
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,China)
Abstract: Objective To prepare benproperine phosphate sustained-release pellets and study its release characteristics. Methods Pellets were prepared by centrifugal-coating granulation method, using Eudragit® NE30D as sustained-release coating material. The effect of the coating level and curing time on the release rate of benproperine phosphate from the sustained-release pellets were studied. Results The coating pellets show an obviously sustained-release effect with the coating level of 3 % and thermal treatment for 24 h. The release characteristics of the coating pellets is basically consistant with sustained-release tablets. Conclusion Benproperine phosphate sustained–release pellets are successfully prepared.
Key word: pharmaceutics; benproperine phosphate; sustained-release pellets; centrifugal-coating granulation; Eudragit® NE 30D
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