【摘要】 目的 通过对慢性胃炎和消化性溃疡患者幽门螺旋杆菌的分离培养和耐药性分析，为幽门螺杆菌感染的根除性治疗提供依据。方法 经胃镜活检快速尿素酶阳性的195例慢性胃病患者，取病变黏膜组织，常规方法培养鉴定幽门螺杆菌，采用平皿稀释法对分离菌株进行药物敏感试验。结果 195例慢性胃炎及消化性溃疡患者中，幽门螺杆菌的分离率高达79.5%。药敏显示，此次分离的幽门螺杆菌对甲硝唑和替硝唑呈现不同程度的耐药，对阿莫西林、克拉霉素敏感。结论 幽门螺杆菌是慢性胃炎和消化性溃疡发病的首要因素，阿莫西林、克拉霉素仍然是根除治疗首选药物。

     【关键词】 消化性溃疡；胃炎；幽门螺杆菌

    Isolation of Helicobacter pylori in patients with chronic gastritis and peptic ulcer and resistant analysis of Helicobacter pylori to antibiotics

    ZHANG Xue-ying，SUN Yan-bo，SHI Hong-yan.Department of Clinical Liboratory，Sino-Japan Unit Hospital，Jilin University，Changchun，130021，China

    【Abstract】 Objective In order to supply the basis of eradicative therapy for Helicobacter pylori infection，isolation of Helicobacter pylori and resistance to antibiotics were carried out. Methods 195 cases of patients with chronic gastritc disease were selected for cultivation of Helicobacter pylori from biopsy ......