米非司酮治疗子宫肌瘤的临床研究及对性激素的影响
子宫肌瘤；米非司酮；性激素,,子宫肌瘤；米非司酮；性激素,1资料与方法,2结果,3讨论,参考文献:
摘要：目的 探讨米非司酮治疗子宫肌瘤的临床疗效和治疗前后血清性激素水平的变化。方法 让确诊为子宫肌瘤的45例患者睡前口服米非司酮25mg，每日1次，连服3个月。治疗前后B超测量子宫及肌瘤体积、血清性激素水平等指标。结果 患者在治疗期间均出现闭经，临床症状明显改善，子宫体积平均缩小32.63%，肌瘤体积平均缩小52.56%。FSH、LH、PRL、E2和P平均浓度较用药前下降，以E2和P下降明显(P<0.01)。结论 米非司酮治疗子宫肌瘤疗效好，副作用轻，为保守治疗子宫肌瘤提供了一条新的治疗途径。关键词：子宫肌瘤；米非司酮；性激素
The Efficacy of Mifepristone on Uterine Myoma
and the Influence of this Drag on Sexual Hormone
LEI Shaoxia,NING Jian，LI Yuanyuan，et al
(Zhangcha Hospital in Chancheng District,Foshan City,Foshan Guangdong 528051,China)
ABSTRACT:Objective To explore the effect of mifepristone on myoma of uterus and the changes of sexual hormones before and after this treatment.Methods 45 patients with uterine myoma were orally administered mifepristone 25mg before sleeping once a day for three months;the sizes of uterus and its myoma were observed in the B type sonogram an the serum sexual hormone, the function of liver and kidney,the blood glucose and lipid were assayed.Results Menostasia was appeared in the period of treatment and clinical symptomes were improved;the sizes of uterus and its myoma were averagely decreased to 32.63% and 52.56% respectively;the mean concentration of FSH,LH,PRL,E2 and P were lower than before treatment,but the concentrations of E2 and P were decreased more significantly(P<0.01).Conclusion It is more effective and less side effects that myoma of uterus is treated by mifepristone,and it may be a new way to conservatively treat uterine myoma. ......
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