KAI1(期刊论文)

KAI1/CD82、ECadherin在宫颈鳞癌组织中的表达及其意义

http://www.100md.com 《中华首席医学网》 2006年第3期

KAI1,CD82；ECadherin；宫颈癌；免疫组化；淋巴结转移,,KAI1,CD82；ECadherin；宫颈癌；免疫组化；淋巴结转移,KAI1,CD82、ECadherin在宫颈鳞

     摘要：目的探讨KAI1/CD82、ECadherin在宫颈鳞癌中的表达及其意义。方法采用免疫组化SP法分别检测KAI1/CD82、ECadherin在10例正常宫颈组织、15例不典型增生宫颈组织及64例宫颈鳞癌中的表达，分析其表达结果与临床病理特征的关系。结果随着从正常宫颈组织→宫颈不典型增生组织→宫颈鳞癌的转化，二者的阳性表达率呈递减趋势。在宫颈鳞癌中的表达率明显低于正常组织和不典型增生组织(P<0.05)，而正常组织与宫颈不典型增生组织之间无显著性差异(P>0.05)。二者在宫颈组织中的表达呈正相关，且二者在宫颈鳞癌中的共表达下调与淋巴结转移明显相关。结论 KAI1/CD82可能与膜蛋白ECadherin相互作用抑制宫颈鳞癌的淋巴结转移；ECadherin基因、肿瘤自身的特性以及多种基因相互作用可能在宫颈鳞癌的转移中起着更为关键的作用。

     关键词：KAI1/CD82；ECadherin；宫颈癌；免疫组化；淋巴结转移

    Expression and significance of KAI1/CD82 and ECadherin in Human squamous cervical carcinoma

    Wang Guoqing, Li Mingzhong, Liu Zi

    (Department of Gynecology Oncology, Shaanxi Province Cancer Hospital, Xian 710061;Department of Tumor Radiotheray, the First Affiliated Hospital,Medical School of Xian Jiaotong University, Xian 710061, China)

    ABSTRACT: Objective To investigate the expression and significance of KAI1/CD82 and ECadherin in human squamous cervical carcinoma. Methods The expressions of KAI1/CD82 and ECadherin were examined respectively by immunohistochemical SP method in 10 cases of normal cervical tissue, 15 cases of atypical hyperplasia of cervical epithelia and 64 cases of squamous cervical carcinoma. We analyzed statistically the correlation between the immunohistochemical results and the clinicopathological features. Results From normal cervical tissue, Cervical intraepithelial neoplasis(CIN) to cervical cancer, the positive expression rates of KAI1/CD82 and ECadherin were gradually decreased. Through statistic test, the positive expression rates of both invasive squamous carcinoma of the cervix were significantly lower in normal cervical tissue and CIN(P<0.05), while it was of no statistical significance between the latter two(P>0.05). Of all the samples, direct correlation was showed in the expressions of KAI1/CD82 and ECadherin. Furthermore, the lowexpression of both revealed significant correlation with lymphonode metastasis in human squamous cervical carcinoma. Conclusion KAI1/CD82 and ECadherin interactions may depress lymphonode metastasis in cervical carcinoma. Logistic analysis reveals that ECadherin gene, specific and interactions of several genes may be more significant during tumor metastasis. ......

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