[摘要] 目的 探讨血清降钙素原(PCT)测定在新生儿感染性疾病中的意义。方法 采用半定量固相免疫色谱法检测96例感染性疾病新生儿和30例非感染性疾病新生儿血清PCT值。结果 细菌感染组血清PCT阳性率显著高于病毒感染组(P<0.01)，若以PCT>0.50ng/ml为阳性阈值，则PCT对新生儿细菌感染诊断的敏感性、特异性、阳性预测值、阴性预测值分别为77.05%、80.00%、87.04%、66.67%；15例败血症新生儿血清PCT值均明显升高；未感染组血清PCT值均未见升高。结论 血清PCT检测可作为新生儿细菌感染及败血症时的一个新的重要诊断参数和指标。

    [关键词] 降钙素；婴儿，新生；传染病

    Clinical significance of serum procalcitonin in neonatal infectious diseases

    HUANG Cai-zhi,MO Li-ya,JIANG Yu-lian,et al.

    Department of Clinical Laboratory,Hunan Children’s Hospital,Changsha 410007,China

    [Abstract] Objective To evaluate the clinical significance of serum procalcitonin (PCT) in neonatal infectious diseases.Methods Serum PCT were measured by semi-quantitative solid-phase immune chromatography.96 neonates with various infection diseases and 35 neonates with non-infectious diseases were enrolled in this study.Results The positive rate of PCT in bacteria-infected group was significantly higher than that in virus-infected group(P<0.01).Take serum PCT≥0.50ng/ml as a threshold,the sensitivity,specificity,positive predictive value and negative predictive value of the test in diagnosing bacterial infection diseases were 77.05%,80.00%,87.04%,66.67%,respectively.PCT levels increased significantly in 15 neonates with sepsis.Serum concentrations of PCT were found without any significantly change in non-infected group.Conclusion Serum PCT seems to be an important mark for the diagnosis of neonate infectious diseases and sepsis. ......