糖适平治疗2型糖尿病的CGMS动态变化临床观察
2型糖尿病；糖适平；动态血糖监测,,],2型糖尿病；糖适平；动态血糖监测,1资料与方法,2结果,3讨论,[参考文献]
[摘要] 目的 探讨糖适平治疗2型糖尿病的CGMS与多项目指标临床相关性。方法 近年诊断2型糖尿病患者22例，应用美国产动态血糖监测系统(CGMS Mini Med Inc)，测量药物治疗后不间断连续血糖监测曲线，与本药药代动力学水平做一动态分析。结果 口服糖适平2.5h时血糖水平曲线最低平，与其他时段血糖水平曲线差异有极显著性(P<0.001)。其中每日6am口服本药，2.5h时血糖水平曲线为24h时最低平，与其他时段血糖水平曲线差异有极显著性(P<0.001)。口服糖适平7.5h后血糖水平曲线渐次升高，直至再次口服本药后血糖水平曲线渐次降低直至口服糖适平2.5h时血糖水平曲线最低平。每日服药1次，24h血糖水平曲线较不服药者血糖水平曲线明显低平(P<0.001)。结论 每日6am口服本药为最佳服药时间，口服本药2.5h时降糖作用最强；本药可在体内持续作用7.5～24h。[关键词] 2型糖尿病；糖适平；动态血糖监测
Clinical study of CGMS in type 2 diabetic patients treated with gliguidone
LI Changqi,ZHANG Jianhui,FENG Jiaqing,et al.
Endocrine Department,Daqing Longnan Hospital,Daqing 163453,China
[Abstract] Objective To discuss relative indexes in type 2 diabetic patients treated with gliguidone and with continuous glucose monitoring system(CGMS).Methods The blood glucose by CGMS and the concentration of gliguidone in blood were measured in two patients with recently diagnosed type 2 diabete after they were administered with gliguidone.The relation between the blood glucose and the concentration of gliguidone in blood was analyzed.Results The curve of the blood glucose was lowest in 2.5 hours when gliguidone was taken.The blood glucose was significant statistics difference with the other blood glucose respectively(P<0.001).The curve of the blood glucose is lowest at 8∶30 am when gliguidone was administered at 6am and had statistic difference with the other blood glucose a day(P<0.01).The blood glucose gradually rise in 7.5 hours after the administration,and declined to be lowest in 2.5 hours after the medicine was given. The blood glucose of patients who received the medicine once daily was lower than the others(P<0.001).Conclusion The optimal time of the administration is 6am and the blood glucose is lowest in 2.5 hours after the medicine is given.The antidiabetic therapy blood concentration of the medicine sustains about 7.5 to 24 hours. ......
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