淋巴管内皮细胞透明质酸受体-1在胃癌组织中的表达及意义
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李 蕾, 张翠萍, 赵清喜, 刘 晖, 李玉军
胃肿瘤;LYVE-1;淋巴管生成;淋巴管密度;组织芯片,李蕾,张翠萍,赵清喜,刘晖,李玉军,通讯作者:,电话:,收稿日期:,接受日期
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李蕾, 张翠萍, 赵清喜, 青岛大学医学院附属医院消化内科 山东省青岛市 266003
刘晖, 李玉军, 青岛大学医学院附属医院病理科 山东省青岛市 266003
通讯作者: 张翠萍, 266003, 山东省青岛市江苏路16号, 青岛大学医学院附属医院消化科. Jianyilu16@yahoo.com.cn
电话: 0532-82767938
收稿日期: 2006-05-19 接受日期: 2006-07-19
Expression of lymphatic vessel endothelial hyaluronic acid receptor-1 and its significance in gastric cancer
Lei Li, Cui-Ping Zhang, Qing-Xi Zhao, Hui Liu, Yu-Jun Li
Lei Li, Cui-Ping Zhang, Qing-Xi Zhao, Department of Gastroenterology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Hui Liu, Yu-Jun Li, Department of Pathology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Correspondence to: Dr. Cui-Ping Zhang, Department of Gastroenterology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China. Jianyilu16@yahoo.com.cn
Received: 2006-05-19Accepted: 2006-07-19
AbstractAIM: To investigate the expression of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and its clinical significance in gastric cancer.
METHODS: Tissue microarray technique and immunohistochemistry were used to detect the expression of LYVE-1 and lymphatic vessel density (LVD) in 85 cases of gastric cancer tissues and 40 cases of normal gastric tissues.
RESULTS: LYVE-1 was expressed in the endothelial cytoplasm of lymphatic vessels, showing as brown and yellow staining. The values of LYVE-1-positive LVD in gastric cancer and peritumoral tissues were significantly higher than those in normal gastric and intratumoral tissues (7.89 ± 2.14 vs 1.15 ± 1.62, P < 0.01; 9.28 ± 1.18vs 4.75 ± 1.19, P < 0.01). In gastric cancer tissue, the value of LYVE-1-positive LVD was markedly higher in the cases with low differentiation (9.21 ± 2.32), clinical stage Ⅲ-Ⅳ (9.46 ± 2 ......
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